1 – Personalization
The days of anonymous, robotic e-mails are over. Personalization has long since become the norm, even in automated mails. You can either do this via features of your mailing app, or, on the sender's side, by personalizing your sender field.
In this regard, it's also important that you maintain a consistent and personal tone of voice and respond quickly to questions, even if the sender persona is fake. In addition, when you select a name for your mail program, think about the global picture. Names like Gabriel, Nina or Hannah are known worldwide – names like Mehmet, Akira or Diedonné are more tied to specific cultures.
2 – Simplification
People get a lot of mail every day. To make your automated e-mails count, keep them short and sweet. The ideal length is about one screen length on a desktop monitor, so that people don't have to scroll.
In addition, counter to what you may think, experiment with layout-free e-mail. This won't only make them lighter in the inbox, it will also make them easier on the eyes. Plus, it enhances the 'natural' effect, i.e. the impression that your mail may have been written by an actual person rather than being another glitzy marketing tool.